Andrew Huberman on nicotine gum and pouches: Benefits and risks | Lex Fridman Podcast Clips - 双语字幕
Nicotine is an interesting compound.
It will raise blood pressure, and it is probably not safe for everybody, but is gaining in popularity, like mainly these...
Pouches that people put in the lip not we're not talking about I'm smoking vaping dipping or snuffing
you know my
interest in nicotine started this was in 2010 I was visiting Columbia medical school and I was in the office of
The great neurobiologist Richard Axel won the Nobel Prize Co-recipient with Linda Buck for the discovery of the molecular basis of olfaction brilliant guy.
He's probably in his late 70s now.
Probably.
Yeah.
And kept popping nikorette in his mouth.
And was like, what's this about?
And he said, oh, well, this was just anecdote, right?
But he said, everybody said this.
He said, oh, well, you it protects against Parkinson's and Alzheimer's.
I said, it does.
And goes, yeah, I don't know if he was kidding or not.
He's known for making jokes.
And then he said that when he used to smoke,
it really helped us focus in creativity, but then he quit smoking because he didn't want lung cancer.
And he found that he couldn't focus as well.
So he occasionally, like right now, well, each, I do a half a piece, but I'm not Russian.
So I'm a little,
you know,
did you just So,
I'll do a couple milligrams every now and again,
and it definitely sharpens the mind on an empty stomach in but you fast all day,
you're still doing one meal a One meal a Yeah.
I a nicotine pouch with Rogan at dinner.
I got high.
Yeah, that's a lot.
That's like usually six or eight milligrams.
I know people get a canister of Zen, take one a day, pretty soon they're taking a canister a day.
So you have to be very careful.
I will only allow myself two pieces of knicker at total per week.
And you will notice that in the day after you use it,
sometimes your throat will feel a little spasmy, like you might want to cough once or twice.
And so, you know, if you're a singer or your podcast or something, you have to do long podcasts.
You want to just be mindful of it.
But you're supposed to kind of like keep it in your cheek and, you know, here we go.
But it did make me intensely focused in a way that was a little bit scary because the nucleus is in the,
you know, basal forebrain nucleus has colonergic neurons that radiate out axons and little wires that release acetylcholine into the neocortex and elsewhere.
And you focus on one particular topic matter or one particular area of your visual
field or listening to something and focusing
We know that there's an elaboration of the amount of acetylcholine released there and it binds to nicotinic acetylcholine receptor sites there.
So it's a kind of an intentional modulation by acetylcholine.
So getting it with nicotine, you're a exogenous or artificial heightening of that.
Circuitry and the time I had talk of Carlson on the podcast.
He told me that apparently it helps him as he said publicly keep his
Love life vibrant really it caused a basic constriction like he literally said it makes it take very hard He said that publicly also.
Okay.
Well as little as I want to think about tucker carlson's trust um sex life um no disrespect
uh the
Major effect of nicotine on the vasculature my understanding is that it causes vasoconstriction not
vasodilation drugs like cialis to dallofil Vigrates that are a base of dilators.
They allow more blood flow nicotine does the opposite, less blood flow to the periphery, but provided dosages are kept low.
I don't recommend people use it frequently or at all,
and I don't recommend young people use it 25 and younger, brain's very plastic at that.
time.
And certainly, smoking, dipping, vaping, it's nothing, aren't good because you're going to run into trouble for other reasons.
But in any case, even there, vaping is a controversial topic.
Probably safer than smoking, but has its own issue.
I said something like that, and boy, did I catch a lot of heat for that.
I can't say anything as a health science educator and not piss somebody off.
It just depends on where the center of mass is and how far outside that you are.
For me, the caffeine is the main thing.
And actually,
it's a really big part of my life, and of the things you recommend that people wait a bit in the morning to consume caffeine.
they experience a crash in the afternoon.
This is one of the misconceptions I regret maybe even discussing it for people that crash in the afternoon.
often times if they delay their caffeine by 60 and 90 minutes in the morning, they will offset some of that.
But if you eat a lunch that's too big or you didn't sleep all the night before, you're not going to avoid that afternoon crash.
But I'll wake up sometimes and go straight to hydration caffeine, especially if I'm going to out.
Here's a weird one.
If I exercise before 830 a.m., especially if I start exercising when I'm a little bit tired, I get energy that lasts all day.
If I wait until my peak of energy,
which is mid morning, 10 a.m., 11 a.m., and I start exercising then, I'm basically exhausted all afternoon.
And I don't understand why.
I mean, it depends on the intensity of the workout.
But I like to be done, showered, and heading into work by now.
But I don't always meet that more.
So you're saying it doesn't affect your energy if you start with exercising.
I think you can get energy and wake yourself up with exercise if you start early.
And then that fuels you all day long.
I think that if you wait until you're feeling at your best to train.
Sometimes that's detrimental because then in the afternoon when you're doing like the work we get paid for like research podcasting etc then oftentimes you know your brain isn't firing as well.
I haven't really rigorously tried that wake up and just start running or lives with the jocko thing and then there's this phenomenon called entrainment where if you force yourself to exercise or
eat or socialize or view bright light at a certain time of day for three to seven days in a row,
pretty soon there's an anticipatory circuit that gets generated.
This is why anyone in theory can become a morning person to some degree or another.
And this is also beautiful example of why you wake up before your alarm clock goes off,
you people wake up and all of a it goes off.
It wasn't because it clicked because you have this incredible time keeping mechanism that exists in sleep.
And there's some papers that have been published in the last couple of years,
Nature Neuroscience and elsewhere showing that people can answer math problems in their sleep, simple math problem.
Math problems none the less.
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